Bulletin de veille Perturbateurs endocriniens, n°32, octobre 2025
Exposition professionnelle
Multiple maternal occupational exposures during pregnancy and intrauterine growth: analysis of the French Longitudinal Study of Children - ELFE cohort, using data-driven approaches.
Tartaglia M, Ge C, Pronk A, Costet N, Audignon-Durand S, Houot MT, et al. Int J Hyg Environ Health. 2025 Sep 5;270:114666. Lien vers l'article
Phthalate exposure is associated with subclinical coronary atherosclerosis: The Aragon Workers' Health Study (AWHS).
Mérida DM, Torrijo-Belanche C, Moreno-Franco B, Laclaustra M, Rey-García J, Gimeno-Ruiz S, et al. Am J Prev Cardiol. 2025 Sep;23:101072. Lien vers l'article
The effects of parental occupational exposures on autism spectrum disorder severity and skills in cognitive and adaptive domains in children with autism spectrum disorder.
McCanlies EC, Gu JK, Ma CC, Sanderson WT, Ludeña-Rodriguez YJ, Hertz-Picciotto I. Int J Hyg Environ Health. 2025 Jul;268:114613. Lien vers l'article
Occupational Exposure to Engine Exhausts and Prostate Cancer Risk,
Barul, C., Rousseau, M. C. and Parent, M. E., Environmental Health, Jul 25 2025, Vol. 24, no. 1.
https://doi.org/10.1186/s12940-025-01205-3
PFAS (substances per et polyfluorées) : définition, toxicité, exposition des pompiers,
Bonneterre, V. and Persoons, R., Archives des Maladies Professionnelles et de l'Environnement, 2025/10/01, Vol. 86, no. 5, p. 102897.
https://doi.org/10.1016/j.admp.2025.102897
A Scoping Review on Male-Mediated Developmental Toxicity,
Caporossi, L., Castellano, P., Paci, E. and Pigini, D., Toxics, Aug 22 2025, Vol. 13, no. 9.
https://doi.org/10.3390/toxics13090707
Exposure to Lead Compounds in an Industrial Setting and the Effects on the Thyroid Gland: A Pilot Cohort Study,
Caporossi, L., Di Renzi, S., De Rosa, M., Capanna, S., Partenzi, E., D'alessandro, I. and Papaleo, B., Hygiene, Apr 3 2025, Vol. 5, no. 2.
https://doi.org/10.3390/hygiene5020013
Environmental and occupational risks to reproductive health in women service members and veterans,
Clark, K. L., Frontiers in Public Health, Aug 13 2025, Vol. 13.
https://doi.org/10.3389/fpubh.2025.1628858
Endocrine disruptors and male infertility: multi-omics identification of key genes in non-obstructive azoospermia,
Hong, Y. G., Wang, Y. R., Li, J. J., Shu, W. Y., Chen, H. L. and Chen, C. D., Journal of Assisted Reproduction and Genetics, 2025.
https://doi.org/10.1007/s10815-025-03664-6
Breast cancer-related occupational exposures facing immigrant women,
Knox, K. E., Ohayon, J. L., Carrera, E., Rudel, R. A. and Morello-Frosch, R., Journal of Exposure Science and Environmental Epidemiology, 2025.
https://doi.org/10.1038/s41370-025-00808-9
Circular RNA hsa_circ_0099188 regulates inducible nitric oxide synthase and chemokine transcription in macrophages by targeting the hsa-miR-381-3p/PPP3CA and hsa-miR-381-3p/KLF4 pathways in response to 4,4′-methylene diphenyl diisocyanate-glutathione conjugate exposure,
Lin, C. C., Law, B. F. and Hettick, J. M., Toxicological Sciences, 2025.
https://doi.org/10.1093/toxsci/kfaf114
Epidémiologie
Longitudinal analysis of maternal exposure to phthalates and bisphenol A and their impact on infant neurodevelopment and autistic behavior: The potential mediating role of thyroid hormones,
Al-Saleh, I., Aljerayed, Y., Gheith, M., Alobaid, N., Alenazi, H., Elkhatib, R., Aldhalaan, H., Alnemer, M., Mohamed, G. and Shoukri, M., International Journal of Hygiene and Environmental Health, Aug 2025, Vol. 269.
https://doi.org/10.1016/j.ijheh.2025.114647
Role of phthalates in breast cancer initiation, progression and drug rersistance: A scoping review and recommendations,
Benoit, L., Tomkiewicz, C., Bortoli, S., Bats, A. S., Coumoul, X. and Koual, M., Toxicology Letters, Nov 2025, Vol. 413.
https://doi.org/10.1016/j.toxlet.2025.111721
Maternal phthalate exposure, gestational length, and preterm birth risk: a prospective cohort study nested within a randomised trial,
Best, K. P., Yelland, L. N., Ge, L., Shi, Z. M., Leemaqz, S., Gibson, R., Makrides, M. and Middleton, P., Bmc Pregnancy and Childbirth, Aug 8 2025, Vol. 25, no. 1.
https://doi.org/10.1186/s12884-025-07980-8
Associations Between Prenatal Phthalate Exposure and Atopic Symptoms in Childhood: Effect Modification by Child Sex,
Bhatt, K. D., Mistry, S., Lamadrid-Figueroa, H., Tamayo-Ortiz, M., Mercado-Garcia, A., Lane, J. M., Tellez-Rojo, M. M., Wright, R. O., Wright, R. J., Estrada-Gutierrez, G., Carroll, K. N., Alcala, C. S. and Rosa, M. J., Toxics, Sep 3 2025, Vol. 13, no. 9.
https://doi.org/10.3390/toxics13090749
Integrated network toxicology and population-based analysis uncovers organophosphate flame retardant exposure as a risk factor for hepatic steatosis and fibrosis: mechanistic and clinical insights,
Che, L., Jiang, R. J., Wang, C. Q., He, J. L., Zhang, Z. Y. and Qian, B., International Journal of Surgery, Sep 2025, Vol. 111, no. 9, p. 6036-6049.
https://doi.org/10.1097/js9.0000000000002680
The effect of phytoestrogens and PAHs on endometriosis and the involvement of gut microbiota, inflammation, and molecular targets,
Chen, Y. L., Jiang, Y. T., Li, Z. Y., Zhu, M. Y., Akimana, A. G., Wang, K., Zhou, K., Zhang, X. L., Ji, X. M. and Chen, M. J., Scientific Reports, Oct 15 2025, Vol. 15, no. 1.
https://doi.org/10.1038/s41598-025-20042-5
Prenatal and early childhood exposure to phthalates and neurodevelopment in 42 months old children,
Cohen-Eliraz, L., Ornoy, A., Ein-Mor, E., Bar-Nitsan, M., Calderon-Margalit, R. and Pilowsky-Peleg, T., Neurotoxicology, Sep 2025, Vol. 110, p. 74-84.
https://doi.org/10.1016/j.neuro.2025.07.007
A scoping review of the role of heritability and environmental exposures in the development and severity of benign prostatic hyperplasia,
Daryabari, S. S., Fendereski, K., Grimes, M. D., Gross, K. X., Summers, S., Ramsay, J. M. and Myers, J. B., Translational Andrology and Urology, Aug 2025, Vol. 14, no. 8, p. 2439-2455.
https://doi.org/10.21037/tau-2025-342
Prenatal exposure to bisphenol-A and neurocognitive changes in children aged 2 to 5 years: a systematic review,
De Oliveira, I. V. M., De Albuquerque, F. M., Fernandes, A. D., Zanella, P. B. and Silva, M. A., Reviews on Environmental Health, 2025.
https://doi.org/10.1515/reveh-2024-0161
Breast milk bisphenol concentrations in Canada and South Africa and associations with body size among South African infants,
Elsiwi, B., Bayen, S., Chi, Z. H., Goodyer, C. G., Hales, B. F., Robaire, B., Bornman, R., Obida, M., Moodie, E. E. M. and Chevrier, J., Environmental Research, Nov 15 2025, Vol. 285.
https://doi.org/10.1016/j.envres.2025.122452
Human liver perfluorooctane sulfonate associates with steatotic liver disease in a sex-dependent manner,
Flam, E., Lienard, V., Raverdy, V., Derhourhi, M., Froguel, P., Bonnefond, A., Lefebvre, P., Pattou, F., Eberle, D., Haas, J. T. and Staels, B., Environment International, Oct 2025, Vol. 204.
https://doi.org/10.1016/j.envint.2025.109838
The link between prenatal exposure to a chemical mixture, cord blood hormones, and birth weight: an epidemiologic study,
Govarts, E., Cox, B., Portengen, L., Rodriguez-Carrillo, A., Carsique, M., Covaci, A., Den Hond, E., De Henauw, S., Nawrot, T., Leermakers, M., Patteet, L., Schettgen, T., Crepet, A., Van Klaveren, J., Vermeulen, R. and Schoeters, G., Environment International, Aug 2025, Vol. 202.
https://doi.org/10.1016/j.envint.2025.109700
The impact, mechanisms and prevention strategies of environmental endocrine disruptors on male reproductive health,
Han, X. Y. and Jin, X. L., Frontiers in Endocrinology, Oct 1 2025, Vol. 16.
https://doi.org/10.3389/fendo.2025.1573526
Endocrine and Reproductive Health Considerations of Sunscreen UV Filters: Insights from a Comprehensive Review 2014-2024,
Jaskulak, M., Cinkusz, M., Franchuk, K. and Zorena, K., Current Environmental Health Reports, Aug 2 2025, Vol. 12, no. 1.
https://doi.org/10.1007/s40572-025-00492-9
Serum concentrations of perfluoroalkyl and polyfluoroalkyl substances and risk of ovarian cancer,
Jones, R. R., Madrigal, J. M., Medgyesi, D. N., Fisher, J. A., Calafat, A. M., Botelho, J. C., Kato, K., Albert, P. S., Silverman, D. T., Hofmann, J. N. and Trabert, B., Jnci-Journal of the National Cancer Institute, 2025.
https://doi.org/10.1093/jnci/djaf204
Evaluating health impacts of exposure to PFAS mixtures: a systematic review of epidemiological studies using mixture methods,
Kemp, M. J., Thoppe, K., Jones, K., Maltby, M., Ball, K. and Barlow, C. A., Critical Reviews in Toxicology, Sep 14 2025, Vol. 55, no. 8, p. 777-795.
https://doi.org/10.1080/10408444.2025.2546427
Investigating the association between bisphenols and diabetes: Evidence from epidemiological and bioinformatics,
Li, J., Zhao, Y. P., Liu, H., Yang, P. P., Yang, S. and Liang, G. Y., Ecotoxicology and Environmental Safety, Oct 1 2025, Vol. 304.
https://doi.org/10.1016/j.ecoenv.2025.119105
Effects of single and multiple endocrine-disrupting chemical exposures on hyperactivity trajectories among preschoolers: A cohort study,
Li, R. Y., Li, S. Q., Zhou, Y., Xiao, W., Xu, H. Q., Tao, X. Y., Xie, J. A. and Wan, Y. H., Environment International, Oct 2025, Vol. 204.
https://doi.org/10.1016/j.envint.2025.109825
Personal care product use and risk of adult-onset asthma: Prospective cohort analyses of US Women from the Sister Study,
Lim, J., Chang, C. J., White, A. J., Lo, S., Wang, H. T., Goodney, G. A., Miao, R., Barochia, A., Sandler, D. P. and Wong, J. Y. Y., Environment International, Aug 2025, Vol. 202.
https://doi.org/10.1016/j.envint.2025.109681
Associations between per- and polyfluoroalkyl substances (PFAS) exposure via infant feeding and the gut microbiota of preterm infants: A study of mother-preterm infant dyads,
Lin, B. C., Zhu, L., Xu, H., Xiao, Y. P., Xu, J. Q., Huang, Y. F., Yang, C. Z., Wang, M. Q., Bai, Z. J., Zhu, W., Wei, Y. H., Li, H. T. and Chen, Y. R., Ecotoxicology and Environmental Safety, Sep 15 2025, Vol. 303.
https://doi.org/10.1016/j.ecoenv.2025.118853
Prenatal microplastic exposure and umbilical cord blood androgenic and glucocorticoid hormones,
Liu, B. Y., Zheng, D. M., Wang, J., Wang, D., Zhang, S. and Chu, D. M., Ecotoxicology and Environmental Safety, Sep 15 2025, Vol. 303.
https://doi.org/10.1016/j.ecoenv.2025.118827
Multielemental Profile for Seminal Plasma Through Inductively Coupled Plasma-Tandem Mass Spectrometry and Its Relationship with Seminal Parameters, Spermatic Biomarkers, and Oxidative Stress,
López-Botella, A., Cenitagoya-Alonso, N., Sánchez-Romero, R., Sáez-Espinosa, P., Hernández-Falcó, M., Gómez-Torres, M. J. and Todoli-Torró, J. L., Antioxidants, Sep 15 2025, Vol. 14, no. 9.
https://doi.org/10.3390/antiox14091118
Randomised controlled trial of a low plastic diet and lifestyle intervention for adults with cardiometabolic risk factors: the Plastic Exposure Reduction Transforms Health (PERTH) trial - a protocol,
Lucas, A., Harray, A., Duong, L., Herrmann, S., Vlaskovsky, P., Trevenen, M., Chan, D., Papendorf, H., , M., Bmj Open, Aug 25 2025, Vol. 15, no. 8.
https://doi.org/10.1136/bmjopen-2025-099330
Endocrine-disrupting chemicals exposure: cardiometabolic health risk in humans,
Ma, C. X., Ma, X. N., Li, H. L., Mauricio, D. and Fu, S. B., Cardiovascular Diabetology, Oct 1 2025, Vol. 24, no. 1.
https://doi.org/10.1186/s12933-025-02938-8
Molecular Alterations in Semen of Per-And Polyfluoroalkyl Substance Exposed Subjects: Association Between DNA Integrity, Antioxidant Capacity and Lipoperoxides,
Marinaro, C., Bianchi, A. R., Guerretti, V., Barricelli, G., Berman, B., Bertola, F., Micali, S., Busardò, F. P., Di Giorgi, A., De Maio, A., Piscopo, M., Montano, L. and Lettieri, G., Antioxidants, Jun 27 2025, Vol. 14, no. 7.
https://doi.org/10.3390/antiox14070792
Endocrine disruptive chemicals (EDCs) and autoimmune thyroid diseases (AITD): A systematic literature review,
Monaghan, M., Rodrigues, S., Sharma, S., Leung, A. M. and Van Gerwen, M., Current Opinion in Endocrine and Metabolic Research, Dec 2025, Vol. 41.
https://doi.org/10.1016/j.coemr.2025.100585
Endocrine disrupting chemicals in maternal and umbilical cord plasma and their associations with birthweight in the GUSTO cohort,
Ng, S., Chen, L. W., Chen, Z. Y., Chen, M. H., Chu, A. H. Y., Godfrey, K. M., Tan, K. H., Gluckman, P. D., Eriksson, J. G., Yap, F., Chen, P. C., Chong, Y. S., Chen, C. Y. and Chan, S. Y., Environmental Health, Aug 18 2025, Vol. 24, no. 1.
https://doi.org/10.1186/s12940-025-01202-6
Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood,
Omichessan, H., Dragic, D., Perduca, V., Truong, T., Polidoro, S., Kvaskoff, M., Cano-Sancho, G., Antignac, J. P., Baglietto, L., Mancini, F. R. and Severi, G., Frontiers in Public Health, Jul 28 2025, Vol. 13.
https://doi.org/10.3389/fpubh.2025.1621495
Impact of plastic-related chemicals on emotional and behavioral health in children from Poland,
Polanska, K., Jankowska, A., Bury, D., Moos, R. K., Pälmke, C., Jerzynska, J., Jurewicz, J., Bose-O'reilly, S., Koch, H. M. and Garí, M., Environmental Health, Oct 14 2025, Vol. 24, no. 1.
https://doi.org/10.1186/s12940-025-01210-6
Paraben exposures and satiety hormones in preschool children: an ENVIRONAGE study,
Reimann, B., De Ruyter, T., Sleurs, H., Rasking, L., Verheyen, L., Giesberts, N., Pirard, C., Charlier, C., Frost, G., Vineis, P., De Henauw, S., Michels, N., Nawrot, T. S. and Plusquin, M., Environmental Research, Nov 15 2025, Vol. 285.
https://doi.org/10.1016/j.envres.2025.122300
Associations between chronic exposure to bisphenols and parabens and gut microbiota in children,
Rodrigo, L., Bressa, C., Larrosa, M., Ramírez, V., Gil-Izquierdo, A., Sánchez-Muñoz, C., Martínez-Burgos, M. A., Zafra-Gómez, A. and Rivas, A., Environmental Research, Nov 15 2025, Vol. 285.
https://doi.org/10.1016/j.envres.2025.122643
Beyond Genes: Mechanistic and Epidemiological Insights into Paternal Environmental Influence on Offspring Health,
Rotem, R. S., Hernández-Díaz, S., Hauser, R. and Weisskopf, M. G., Current Environmental Health Reports, Aug 9 2025, Vol. 12, no. 1.
https://doi.org/10.1007/s40572-025-00488-5
Associations between urinary biomarkers of phthalates and phthalate alternatives and female sexual function in a North American cohort,
Schildroth, S., Bond, J., Wesselink, A. K., Koenig, M. R., Calafat, A. M., Botelho, J. C., Abrams, J. and Wise, L. A., Journal of Sexual Medicine, Oct 2025, Vol. 22, no. 10, p. 1766-1779.
https://doi.org/10.1093/jsxmed/qdaf205
Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects,
Swan, J., Zhurenko, D., Huttunen, K. M. and Rysä, J., Archives of Toxicology, 2025.
https://doi.org/10.1007/s00204-025-04203-z
Association between exposure to perfluoroalkyl compounds during early pregnancy and risk of late miscarriage: The Japan Environment and Children's Study,
Tatsuta, N., Iwai-Shimada, M., Isobe, T., Nakayama, S. F., Sekiyama, M., Takagi, M., Kobayashi, Y., Taniguchi, Y., Yamazaki, S. and Japan Environm Childrens Study, G., International Journal of Hygiene and Environmental Health, Sep 2025, Vol. 270.
https://doi.org/10.1016/j.ijheh.2025.114673
Associations Between Endocrine-Disrupting Chemical Exposure and Fertility Outcomes: A Decade of Human Epidemiological Evidence,
Tzouma, Z., Dourou, P., Diamanti, A., Harizopoulou, V., Papalexis, P., Karampas, G., Liepinaitiene, A., Dedele, A. and Sarantaki, A., Life-Basel, Jun 21 2025, Vol. 15, no. 7.
https://doi.org/10.3390/life15070993
Birth weight in relation to maternal and neonatal biomarker concentration of perfluorooctane sulfonic acid: a meta-analysis and meta-regression from a systematic review,
Wright, J. M., Rappazzo, K. M., Ru, H., Lee, A. L., Dzierlenga, M. W., Bateson, T. F. and Radke, E. G., Journal of Exposure Science and Environmental Epidemiology, 2025.
https://doi.org/10.1038/s41370-025-00798-8
Prenatal exposure to polycyclic aromatic hydrocarbons and the risk of childhood overweight,
Yang, Y., Liu, M. H., Shao, H., Jiang, H. F., Yang, L. and Zhang, X. X., Ecotoxicology and Environmental Safety, Sep 15 2025, Vol. 303.
https://doi.org/10.1016/j.ecoenv.2025.119022
Per- and poly-fluoroalkyl substances exposure and risk of gastrointestinal cancers: a systematic review and meta-analysis,
Zhang, S. R., Kappil, E. M., Zheng, T. Z., Boffetta, P. and Seyyedsalehi, M. S., European Journal of Cancer Prevention, Sep 2025, Vol. 34, no. 5, p. 445-455.
https://doi.org/10.1097/cej.0000000000000935
Sex-specific associations between phthalate exposure and stroke risk: a cross-sectional study integrating molecular mechanisms of vascular dysfunction,
Zhou, H.-Q., Cheng, K.-L., Jin, H.-J., Shen, J. Z. and Wu, D.-H., International Journal of Surgery (London, England), 2025/11/10/ 2025.
https://doi.org/10.1097/JS9.0000000000003762
Hallmarks of EDCs among children in Southern China in Relation with obstructive sleep apnea,
Zhou, L. X., Wang, S. H., Li, D. C., Li, J. H., Wang, X. Y., Zhong, S. Y., Li, X. J., Huang, S. Y., Zeng, C. Y., Duan, T. T., Wu, Y., Qi, G. L., Jing, F. R., Gong, Y. J., Yang, P. and Cheng, H. R., Environment International, Oct 2025, Vol. 204.
https://doi.org/10.1016/j.envint.2025.109829
Toxicité sur l’homme
The impact of perfumes and cosmetic products on human health: a narrative review,
Alblooshi, S., Frontiers in Toxicology, Aug 29 2025, Vol. 7.
https://doi.org/10.3389/ftox.2025.1646075
Effect of Dietary Exposure to Low-Density Polyethylene Microplastics and Their Potential Role as Estrogen Vectors In Vivo,
Al-Jandal, N., Saheb, A. I., Alkhubaizi, A., Akbar, A., Al-Hasan, E., Hussain, S. and Al-Mansour, H., Current Issues in Molecular Biology, Aug 30 2025, Vol. 47, no. 9.
https://doi.org/10.3390/cimb47090701
A Narrative Review of Heavy Metals and Sperm Quality: The Interplay with Antioxidant Imbalance and Reactive Oxygen Species,
Azil, S., Errafii, K., Benkhalifa, M., Louanjli, N., Ghazi, B. and Hamdi, S., Current Issues in Molecular Biology, Aug 13 2025, Vol. 47, no. 8.
https://doi.org/10.3390/cimb47080650
Prenatal exposure to Bisphenol-A as a risk factor for infant neurodevelopment,
Bello-Cortes, I. H., Garcia-Garcia, J. A., Gutierrez-Aguilar, M., Araiza-Olivera, D., Sánchez-Perez, C., Garcia-Cerón, G., Morán-Ramos, S., Tovar, H., Bonilla-Brunner, A. and Garcia-Arrazola, R., Frontiers in Endocrinology, Aug 29 2025, Vol. 16.
https://doi.org/10.3389/fendo.2025.1645540
Human Internal Exposures of Bisphenol A and Six Data-Poor Analogs Predicted by Physiologically Based Kinetic Models with Multimodal Parametrization,
Bigonne, H., Rolof, A., Potapova, I., Sturla, S. J. and Aichinger, G., Environmental Science & Technology, Oct 7 2025, Vol. 59, no. 39, p. 20919-20930.
https://doi.org/10.1021/acs.est.5c00513
Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu,
Buoso, E., Masi, M., Limosani, R. V., Oliviero, C., Saeed, S., Iulini, M., Passoni, F. C., Racchi, M. and Corsini, E., Journal of Xenobiotics, 2025/02// 2025, Vol. 15, no. 1, p. 13.
https://doi.org/10.3390/jox15010013
Perturbateurs endocriniens et spermatogenèse,
C Sonigo, L. F.-G., Réalités en Gynécologie-Obstétrique, no. 226. https://www.realites-pediatriques.com/wp-content/uploads/sites/6/2025/04/06_SONIGO_RGO.pdf
Environmental plastic pollutants and endocrine-related cancer: An updated view,
Cirillo, F., Sergi, V., Malaguarnera, R., Scordamaglia, D., Piro, S., Maggiolini, M., Lappano, R. and Francesco, E. M. D., Ecotoxicology and Environmental Safety, Oct 1 2025, Vol. 304.
https://doi.org/10.1016/j.ecoenv.2025.119077
Thyrotoxic effects of organophosphate insecticides in adults: a bibliometric and meta-analysis,
Diawara, M. O., Pan, G., Yang, X., Alqudaimi, M., Fofana, M., Bafei, S. E. C., Wu, D., Tun, H. M., Liu, Q., Zhang, M. and Xia, Y., International Archives of Occupational and Environmental Health, 2025/09/01/ 2025, Vol. 98, no. 7, p. 631-647.
https://doi.org/10.1007/s00420-025-02159-2
The Detrimental Impact of Bisphenol S (BPS) on Trophoblastic Cells and the Ishikawa Cell Lines: An In Vitro Model of Cytotoxic Effect and Molecular Interactions,
Drakaki, E., Mavrogianni, D., Potiris, A., Xydi-Chrysafi, S., Kotrotsos, P., Thomakos, N., Rodolakis, A., Daskalakis, G. and Domali, E., Biomedicines, Aug 8 2025, Vol. 13, no. 8.
https://doi.org/10.3390/biomedicines13081938
The Role of Endocrine Disrupting Chemicals in the Development of Atherosclerosis,
Fenercioglu, A. K. and Unal, D. O., Cardiovascular Toxicology, Nov 2025, Vol. 25, no. 11, p. 1706-1717.
https://doi.org/10.1007/s12012-025-10054-y
Benzophenones: How ultraviolet filters can interfere with reproduction,
Gomez, J. M. R., Journal of Neuroendocrinology, 2025.
https://doi.org/10.1111/jne.70088
PFBS disrupts lipid metabolism and mitochondrial function in human trophoblast cells,
Happel, J., Mellouk, N., Crute, C. and Feng, L. P., Toxicology, Dec 2025, Vol. 518.
https://doi.org/10.1016/j.tox.2025.154269
Liquid Crystal Monomers and Their Mixtures Alter Nuclear Receptor Signaling and Promote Adipogenesis In Vitro,
Heldman, S. M., Eccles, K. M. and Kassotis, C. D., Endocrinology, Nov 2025, Vol. 166, no. 11.
https://doi.org/10.1210/endocr/bqaf143
Genomic evidence based on eQTL data implicates endocrine disruptors as environmental risk factors for estrogen receptor-positive breast cancer,
Hong, Y. G., Li, J. J., Du, Z. Y., Xu, N., Yang, Q. R., Zhou, J. X. and Shu, W. Y., International Journal of Surgery, Aug 2025, Vol. 111, no. 8, p. 5664-5674.
https://doi.org/10.1097/js9.0000000000002642
Integrative causal and single-cell analyses reveal genes responsive to endocrine disruptors driving human male infertility,
Hong, Y. G., Wang, Y. R., Li, J. J., Shu, W. Y., Chen, H. L. and Chen, C. D., Ecotoxicology and Environmental Safety, Sep 1 2025, Vol. 302.
https://doi.org/10.1016/j.ecoenv.2025.118709
Microplastics and gynecological tumors: An emerging environmental health concern,
Hu, Y. L., Song, Z. H., Li, J. W., Yang, F. Y. and Li, L., Reproductive Toxicology, Oct 2025, Vol. 137.
https://doi.org/10.1016/j.reprotox.2025.109018
The relationship between PFAS exposure and dyslipidemia: an updated review, meta-analysis, and evaluation of bias,
Hussey, M. R., Kornberg, T. G., Sherrick, J. M., Olson, A. M., Kind, J. A. and Perez, A. L., European Journal of Epidemiology, Sep 2025, Vol. 40, no. 9, p. 995-1029.
https://doi.org/10.1007/s10654-025-01271-4
Tetramethyl Bisphenol F: Organ- and System-Specific Toxicity, Current Status, and Perspectives,
Hwang, I., Cui, X. S. and Jeung, E. B., International Journal of Molecular Sciences, Sep 23 2025, Vol. 26, no. 19.
https://doi.org/10.3390/ijms26199280
Impact of nanoplastics on thyroid function: Unraveling cellular biokinetics, molecular mechanisms and human risk assessment,
Iglesias-Hernandez, P., Tarazona, J. V., Manosalva, J., Megias, D., Docando, F., Cañas-Portilla, A. I., Torres-Ruiz, M. and De La Vieja, A., Journal of Hazardous Materials, Oct 15 2025, Vol. 498.
https://doi.org/10.1016/j.jhazmat.2025.139890
The Role of Endocrine Disruptors in Childhood Obesity: Unraveling the Obesogens,
Kapama, A., Stefanaki, C., Mastorakos, G. and Papagianni, M., Hormone Research in Paediatrics, 2025.
https://doi.org/10.1159/000545043
Systematic review and Integrated Approaches to Testing and Assessment (IATA) of PFOA and PFOS for endocrine disrupting effects based on the AOP framework,
Kim, D., Ji, S. and Park, K., Environmental Analysis, Health and Toxicology, 2025/09// 2025, Vol. 40, no. Special Issue, p. e2025s03-00.
https://doi.org/10.5620/eaht.2025s03
The Endocrine-Disrupting Chemical Benzophenone-3 in Concentrations Ranging from 0.001 to 10 μM Does Not Affect the Human Decidualization Process in an In Vitro Setting,
Krausser, K., Howanski, J., Fink, B., Bauer, M., Fischer, F., Romanelli, F., Zenclussen, A. C. and Schumacher, A., International Journal of Molecular Sciences, Sep 24 2025, Vol. 26, no. 19.
https://doi.org/10.3390/ijms26199314
Transformation of Bisphenols by Gut Microbiota: Insights into Species-Specific Pathways and Toxicity Implications,
Lv, M. L., Chen, S. Q., Qin, H., Wang, Y. L., Liu, Y. N., Liu, R. Z., Chen, L. Q., Qu, G. B. and Jiang, G. B., Environmental Science & Technology, Aug 12 2025, Vol. 59, no. 31, p. 16227-16239.
https://doi.org/10.1021/acs.est.5c01820
Potential human health effects of per- and polyfluoroalkyl substances (PFAS) prevalent in aquatic environment: a review,
Mayilswami, S., Raval, N. P., Tomar, R., Sharma, S., Praveena, S. M., Kataria, N., Selvasembian, R., Shanmugam, S. R., Nath, R., Malakar, A., Dutta, S. and Mukherjee, S., Environmental Science-Advances, 2025.
https://doi.org/10.1039/d4va00405a
The Impact of Endocrine Disruptors on the Female Genital Tract Microbiome: A Narrative Review,
Moustakli, E., Grigoriadis, T., Potiris, A., Drakaki, E., Zikopoulos, A., Anagnostaki, I., Zachariou, A., Domali, E., Drakakis, P. and Stavros, S., Life-Basel, Jul 24 2025, Vol. 15, no. 8.
https://doi.org/10.3390/life15081177
Exploring the impact of endocrine disruptors on hormonal regulation and adipose tissue in health and obesity,
Nirenjen, S., Singh, S. A., Begum, R. F., Arun, E., Vellapandian, C. and Narayanan, J., Journal of Endocrinology, Jul 1 2025, Vol. 266, no. 1.
https://doi.org/10.1530/joe-24-0374
Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood (vol 13, 1621495, 2025),
Omichessan, H., Dragic, D., Perduca, V., Truong, T., Polidoro, S., Kvaskoff, M., Cano-Sancho, G., Antignac, J. P., Baglietto, L., Mancini, F. R. and Severi, G., Frontiers in Public Health, Sep 2 2025, Vol. 13.
https://doi.org/10.3389/fpubh.2025.1679534
The Plasticizer Dibutyl Phthalate (DBP) Impairs Pregnancy Vascular Health: Insights into Calcium Signaling and Nitric Oxide Involvement,
Quelhas, A. R., Mariana, M. and Cairrao, E., Journal of Xenobiotics, Aug 6 2025, Vol. 15, no. 4.
https://doi.org/10.3390/jox15040127
Cell-free circulating epigenomic signatures: Non-invasive biomarkers of pregnancy-related outcomes associated with plasticizer exposure,
Rajan, A. K., Mohanty, A., Swain, P., Tiwari, R., Gurjar, V., Srivasatava, R. K. and Mishra, P. K., Reproductive Toxicology, Oct 2025, Vol. 137.
https://doi.org/10.1016/j.reprotox.2025.109000
Bisphenol A Interferes with Mast Cell-Mediated Promotion of Cellular Processes Critical for Spiral Artery Remodeling,
Romanelli, F., Zhang, N. J., Bauer, M., Fink, B., Zenclussen, A. C., Schumacher, A. and Meyer, N., International Journal of Molecular Sciences, Oct 5 2025, Vol. 26, no. 19.
https://doi.org/10.3390/ijms26199706
Exploring the Antagonistic Effects of Bisphenols with Nonmonotonic Dose-Response Curves on the Estrogen Receptor,
Su, J. H., Yang, X. X., Wang, D. Y., Liu, H. A., Kuang, Z. C., Liu, Q. S., Zhou, Q. F. and Jiang, G. B., Environment & Health, 2025.
https://doi.org/10.1021/envhealth.5c00173
Endocrine disruption to metastasis: How phthalates promote breast carcinogenesis,
Tiburcio, D., Parsell, M., Shapiro, H., Adolphe, S., Naranjo, O., George, S. and Toborek, M., Ecotoxicology and Environmental Safety, Sep 15 2025, Vol. 303.
https://doi.org/10.1016/j.ecoenv.2025.118874
Molecular Mechanisms of EDC-Induced Alzheimer's Disease and of Traditional Chinese Medicine Active Substances in Treating AD and Antagonizing EDC-Induced Effects,
Yang, T., Neurochemical Research, Oct 6 2025, Vol. 50, no. 5.
https://doi.org/10.1007/s11064-025-04570-0
Per- and poly-fluoroalkyl substances (PFAS) and human health: a review of exposure routes and potential toxicities across the lifespan,
Yeoh, C. S. L., Alrazihi, L. A., Wong, S. T. and Wong, S. F., Environmental Toxicology and Chemistry, Oct 2025, Vol. 44, no. 10, p. 2754-2786.
https://doi.org/10.1093/etojnl/vgaf172
Polycystic ovary syndrome and organochlorine pesticides: exploring potential links and mechanisms,
Yin, S. S., Yang, W. J., Lin, F. Y., Jia, M., Feng, Y., Chen, Y. H., Bai, X. X., Dong, Y. H., Mao, S. D., Hayat, K. and Jin, X. J., Frontiers in Reproductive Health, Sep 2 2025, Vol. 7.
https://doi.org/10.3389/frph.2025.1563414
Effects of an environmentally relevant mixture of organophosphate esters on the phenotype and function of HepG2 liver cells,
Yu, D. W., Hales, B. F. and Robaire, B., Archives of Toxicology, Dec 2025, Vol. 99, no. 12, p. 5005-5022.
https://doi.org/10.1007/s00204-025-04173-2
Transgenerational hepatotoxicity induced by bisphenol B as a substitute for bisphenol A,
Yue, H. F., Hu, Y. C., Wu, X. Y., Tian, Y. C., Liang, X. M., Zhang, J. Y., Li, B., Zhu, H. Z. and Ji, X. T., Ecotoxicology and Environmental Safety, Sep 1 2025, Vol. 302.
https://doi.org/10.1016/j.ecoenv.2025.118702
Exposure to Bisphenol B and S Increases the Risk of Male Reproductive Dysfunction in Middle Age,
Zhao, S., Ni, H. L., Xiao, Y., Du, J., Han, Y. D., Wang, W. Y., Tang, S. and Yu, M. X., International Journal of Molecular Sciences, Sep 28 2025, Vol. 26, no. 19.
https://doi.org/10.3390/ijms26199507
Environmental Endocrine-Disrupting Chemicals, Pancreatic β-Cells, and Type 2 Diabetes Mellitus,
Zhao, Y. L. and Ou, Y., Clinical Endocrinology, 2025.
https://doi.org/10.1111/cen.70050
Mechanisms of three typical endocrine-disrupting chemicals causing myocardial infarction: Gene-level computational modeling,
Zhou, J. X., Chen, S. S., Zheng, Z. Y., Yuan, W. B., Liu, X. B. and Ni, H. G., Environmental Chemistry and Ecotoxicology, 2025 2025, Vol. 7, p. 1761-1773.
https://doi.org/10.1016/j.enceco.2025.08.009
Machine learning and SHAP-based identification of RNASE1 linking environmental endocrine-disrupting chemicals exposure to atherosclerosis,
Zhou, X., Xiao, Q. L., Guo, X., Wang, W. N. and Huang, M. D., Medicine, Sep 12 2025, Vol. 104, no. 37.
https://doi.org/10.1097/md.0000000000044567
Evaluation de l’exposition
Occitanie : La Lettre de l'Air #32 Pesticides, perturbateurs endocriniens et PFAS (polluants éternels) dans l'air : les résultats d'une première étude inédite en France, 2025 | ATMO Occitanie. https://atmo-occitanie.org/occitanie-la-lettre-de-lair-32-pesticides-perturbateurs-endocriniens-et-pfas-polluants-eternels
Comment se protéger des perturbateurs endocriniens ? 600 étudiants vont mesurer leur exposition aux polluants pendant un an,
France 3 Centre-Val de Loire, 2025/10/27/ 2025. https://france3-regions.franceinfo.fr/centre-val-de-loire/indre-loire/tours/comment-se-proteger-des-perturbateurs-endocriniens-600-etudiants-vont-mesurer-leur-exposition-aux-polluants-pendant-un-an-3239959.html
Perturbateurs endocriniens: un nouvel outil pour évaluer l’exposition des couples infertiles,
Réalités en Gynécologie-Obstétrique, 2025/09// 2025, no. 228. https://fertilyon.com/wp-content/uploads/2025/11/Perturbateurs-endocriniens_oct-2025.pdf
Early-Life Dietary Exposure to Perfluorooctanoic Acid (PFOA) Through Milk Consumption: A Systematic Review,
Ahmadpourmir, H., Taghizadeh, S., Tsarouhas, K., Rakhshani, F., Ebrahimi, V., Tsatsakis, A., Tsitsimpikou, C., Hashemzaei, M. and Rezaee, R., Journal of Applied Toxicology, 2025.
https://doi.org/10.1002/jat.4932
Dioxin and PCB monitoring in Greek food products during the period 2002-2022 and preliminary assessment of general population exposure through the diet,
Costopoulou, D., Vassiliadou, I., Kedikoglou, K., Grigoriou, C. and Leondiadis, L., Food and Chemical Toxicology, Dec 2025, Vol. 206.
https://doi.org/10.1016/j.fct.2025.115717
Assessment of chemical extracts of urban air for endocrine disruption using a serie of in vitro bioassays: a case study in Montreal, Canada,
Gillet, A. P., Dong, H., Liu, L., Akiki, C., Zhang, X., Tian, L., Wania, F., Wade, M. G., Apparicio, P., Bayen, S. and Delbes, G., Chemosphere, 2025/11/15/ 2025, Vol. 393, p. 144760.
https://doi.org/10.1016/j.chemosphere.2025.144760
Per-and polyfluoroalkyl substances (PFAS) in milk and dairy products: a literature review of the occurrence, contamination sources, and health risks,
Hossini, H., Massahi, T., Parnoon, K. and Nouri, M., Food Additives and Contaminants Part a-Chemistry Analysis Control Exposure & Risk Assessment, Sep 2 2025, Vol. 42, no. 9, p. 1284-1296.
https://doi.org/10.1080/19440049.2025.2538224
Evaluation of EDCs (phthalates, bisphenols, parabens, and benzophenones) in coffee: cross-sectional study in Algiers,
Khelfi, A. and Azzouz, M., Food Chemistry, Dec 15 2025, Vol. 495.
https://doi.org/10.1016/j.foodchem.2025.146465
From screening to risk assessment: a comparative study on product usage, human burden, and potential neurotoxicity of novel paraben analogues,
Meng, L. X., Kuang, H. X., Tan, J. H., Li, X. L., Liu, Y., Xiang, M. D., Zhou, Y., Fan, R. F. and Yu, Y. J., Environment International, Oct 2025, Vol. 204.
https://doi.org/10.1016/j.envint.2025.109805
Predicting Dermal Exposure to Semivolatile Organic Compounds Resulting from Direct Contact with Consumer Products,
Song, Z. D., Nian, L. Y., Wu, Y. L., Fan, Y. J., Ren, X. P., Zhang, W. J. and Xu, Y., Environmental Science & Technology, Oct 28 2025, Vol. 59, no. 42, p. 22713-22726.
https://doi.org/10.1021/acs.est.5c06786
Integrated chemical exposome-metabolome profiling of follicular fluid and associations with fertility outcomes during assisted reproduction,
Young, A. S., Gennings, C., Braselton, M. E., Mullins, C. E., Jariwala, P., Liang, D. H., Spencer, J. B., Smith, A. K., Hipp, H., Shang, W. R., Abhari, S., Knight, A. K., Gaskins, A. J. and Walker, D. I., Environment International, Sep 2025, Vol. 203.
https://doi.org/10.1016/j.envint.2025.109787
Méthodes
Advancement of electrochemical sensors in the detection of estrogen steroids in the environment: A critical review,
Farale, H., George, M. and Kanchi, S., Journal of Environmental Chemical Engineering, Oct 2025, Vol. 13, no. 5.
https://doi.org/10.1016/j.jece.2025.119094
A deep-learning approach to predict reproductive toxicity of chemicals using communicative message passing neural network,
He, O. W., Chen, D. X. and Li, Y. M., Frontiers in Toxicology, Jul 22 2025, Vol. 7.
https://doi.org/10.3389/ftox.2025.1640612
Application of the AI-Based Framework for Analyzing the Dynamics of Persistent Organic Pollutants (POPs) in Human Breast Milk,
Jovanovic, G., Bezdan, T., Romanic, S. H., Saric, M. M., Biosic, M., Mendas, G., Stojic, A. and Perisic, M., Toxics, Jul 27 2025, Vol. 13, no. 8.
https://doi.org/10.3390/toxics13080631
Assessment of Endocrine-Disrupting Properties in Cosmetic Ingredients: Focus on UV Filters and Alternative Testing Methods,
Maddaleno, A. S., Guardia-Escote, L., Vinardell, M. P., Teixidó, E. and Mitjans, M., Cosmetics, Aug 16 2025, Vol. 12, no. 4.
https://doi.org/10.3390/cosmetics12040175
Electrochemical Determination of Bisphenol a Using a Drop-Dry Modified Gold Electrode with Metal-Organic Framework, Quantum Dots, and their Composite,
Oloyede, S. O. and Ajibade, P. A., Chemistryopen, 2025.
https://doi.org/10.1002/open.202500327
Tailoring flexible aliphatic covalent organic frameworks with hydroxyl sites: A novel platform for efficient extraction and rapid detection of bisphenols,
Su, L., Wang, L., Zhao, L., Liu, Y., Wang, C., Shao, C., Liu, L., Zhang, D. and Darwish, I. A., Talanta, 2025/11/15/ 2025, Vol. 299, p. 129134.
https://doi.org/10.1016/j.talanta.2025.129134
Machine learning-driven prediction models and mechanistic insights into cardiovascular diseases: deciphering the environmental endocrine disruptors nexus,
Yu, W.-M., Chen, Y.-P., Cheng, A.-L., Zheng, Z.-Y., Wang, J.-W., Liu, X.-B. and Zhou, J.-X., Journal of Translational Medicine, 2025/11/12/ 2025, Vol. 23, no. 1, p. 1272.
https://doi.org/10.1186/s12967-025-07223-6
Non-Targeted Analysis Workflow of Endocrine-Disrupting Chemicals in Ovarian Follicular Fluid: Identification of Parabens by Diagnostic Fragmentation Evidence and Additional Contaminants via Mass Spectral Library Matching,
Zhou, Z. L., Neal, M. S., Foster, W. G. and Feng, Y. L., Acs Measurement Science Au, 2025.
https://doi.org/10.1021/acsmeasuresciau.5c00082
Bioinformatics analysis to identify endocrine-disrupting chemicals targeting key ESCC-related genes,
Zhu, Y. N., Shen, W. T. and Li, M. Y., Toxicology Mechanisms and Methods, 2025.
https://doi.org/10.1080/15376516.2025.2543347
Documents INRS
Perturbateurs endocriniens,
Travail et sécurité, INRS, n°873, p.50, septembre 2025
Réponse d'un expert INRS à la question suivante : en entreprise, comment prévenir les risques liés aux perturbateurs endocriniens ?
Les perturbateurs endocriniens,
Dépliant INRS, ED 6377, 2ème édition, 2025
Ce dépliant fait le point sur les risques liés aux perturbateurs endocriniens en milieu de travail. Après avoir rappelé la définition d'un perturbateur endocrinien, il répertorie les sources d'exposition et les effets potentiels sur la santé, et rappelle les règles générales de prévention.
https://www.inrs.fr/media.html?refINRS=ED%206377
Replay du webinaire : Perturbateurs endocriniens : les repérer pour prévenir les risques en entreprise – INRS, novembre 2025
Comment repérer et inventorier les perturbateurs endocriniens et les produits qui en contiennent en milieu professionnel ? Quels outils utiliser ? Quelles sont les sources et les situations d’exposition ? Quelles sont les grandes lignes de la démarche prévention ? Ce webinaire est destiné à tous ceux qui souhaitent identifier et repérer les perturbateurs endocriniens dans leur entreprise, et mettre en place des mesures de prévention adaptées. https://www.inrs.fr/media.html?refINRS=Anim-498
Perturbateurs endocriniens : un nouvel outil pour les repérer en milieu de travail
GHEZZI-TOURNADE F. ; RICAUD M. Références en santé au travail, n°183, pages 5-6, septembre 2025, INRS.
L'INRS met à disposition un nouvel outil de repérage des perturbateurs endocriniens et actualise son dossier web sur le sujet https://www.inrs.fr/media.html?refINRS=AC%20196
Repérage des perturbateurs endocriniens en entreprise - Outil - INRS.
avril 2025
Cet outil d'aide au repérage des perturbateurs endocriniens en milieu de travail rassemble 344 substances chimiques, produites en grande quantité et classées pour leurs effets avérés ou potentiels de perturbation endocrinienne (par l'Anses et/ou par le site institutionnel EDLists). Pour chaque substance, les principaux secteurs industriels et usages (passés et actuels) concernés sont recensés. Sont également renseignés pour chaque substance, le numéro CAS, la catégorie au regard des effets de perturbation endocrinienne sur la santé, et le cas échéant, la classification CMR (règlement européen CLP), le ou les tableaux de maladies professionnelles ainsi que la fiche toxicologique associés. https://www.inrs.fr/media.html?refINRS=outil16
Evaluation du danger des substances chimiques : des différences selon le sexe mieux comprises, mais des lacunes à combler
SPONNE I. ; DARNE C. ; VALENTINO S. Hygiène et sécurité du travail, n°280, p. 49-56, septembre 2025, INRS
En avril 2022, chez l'humain, on comptait 19 969 gènes codant pour des protéines. Que l’on soit homme ou femme, 99 % de ces gènes sont identiques. Pour autant, le capital chromosomique sexuel des hommes et des femmes est à l’origine de sensibilités différentes vis-à-vis de l’environnement. Le sexe est donc une variable essentielle à intégrer au moment de l'évaluation d’un danger et de la caractérisation de la toxicité des substances chimiques rencontrées en milieu professionnel ; cette toxicité peut aussi affecter la descendance de la personne exposée. Cet article met en relief les connaissances acquises sur les différences de toxicité liées au sexe et celles restant à développer pour mieux évaluer le danger des substances chimiques et les risques professionnels auxquels les travailleuses et travailleurs sont exposés. https://www.inrs.fr/media.html?refINRS=DO%2049-5
Agenda, politique, actualité, société et évaluation du caractère PE des substances
2026 Environmental Endocrine Disruptors Conference GRC.
The 2026 GRC on Environmental Endocrine Disruptors will be framed around four cutting-edge multidisciplinary topics: 1) the identification of new EEDs and disease pathways altered by these chemicals; 2) emerging technologies to measure EEDs and model their effects, including the development of New Approach Methodologies (NAMs) and methods to evaluate mixtures; 3) the influence of individual characteristics (like occupation, sex, and age) on exposures and effects of EEDs; and 4) mitigating the effects of EEDs through personalized interventions, policies, and regulations. With its focus on emerging approaches and interventions, discussion will emphasize ways to integrate results from laboratory studies, wildlife studies, and epidemiological studies; using this approach will allow participants to obtain a comprehensive, translational view of how EEDs affect the health of individuals, populations, and ecosystems.
https://www.grc.org/environmental-endocrine-disruptors-conference/2026/
leanScreen : un nouvel outil pour la substitution des PFAS dans l’industrie électronique, INERIS
ChemFORWARD lance une application destinée à soutenir la formulation de nettoyants et dégraissants plus sûrs pour l'industrie électronique
https://substitution-perfluores.ineris.fr/fr/node/281
Commission restricts the use of ‘forever chemicals' in firefighting foams,
European Commission
Today, the Commission adopted new measures restricting the use of PFAS (per- and polyfluoroalkyl substances) in firefighting foams under the REACH Regulation, the EU's chemicals legislation. This is an important measure that protects people and the environment from the risks posed by PFAS.https://ec.europa.eu/commission/presscorner/detail/en/ip_25_2286
Consultation on PFAS draft opinion – Guidance for respondents, ECHA
L'Agence européenne des produits chimiques prévoit de lancer une consultation sur le projet d'avis de son Comité d'analyse socio-économique (SEAC) concernant la restriction proposée à l'échelle de l'UE des substances perfluoroalkylées et polyfluoroalkylées (PFAS) à la suite de la réunion du Comité en mars 2026. La consultation se déroulera au moyen d'un questionnaire structuré, invitant les participants à répondre à des questions sur les impacts potentiels d'une restriction de l'utilisation des PFAS dans différents secteurs. Il leur sera également demandé de fournir des informations précises sur la disponibilité et la faisabilité d'alternatives à ces substances chimiques largement utilisées. Le replay du webinaire qui détaille l'objectif de la consultation, la structure du questionnaire de consultation, le type d'informations est demandé dans l'enquête et comment préparer les données pour la consultation, est disponible
https://echa.europa.eu/-/webinar-consultation-on-pfas-draft-opinion
Highlights from September RAC and SEAC meetings. ECHA
Lors de leurs réunions de septembre, les comités d’évaluation des risques (RAC) et d’analyse socio-économique (SEAC) ont poursuivi l’évaluation de la proposition européenne visant à limiter l’utilisation des substances perfluoroalkylées et polyfluoroalkylées (PFAS) . Le SEAC a formulé des conclusions provisoires concernant l’utilisation des PFAS dans les secteurs de l’énergie et des lubrifiants, tandis que le RAC a formulé des conclusions provisoires concernant l’électronique et les semi-conducteurs. Les deux comités ont entamé des discussions sur la fabrication des PFAS et ont continué d’examiner des questions transversales telles que les seuils de concentration au-delà desquels l’utilisation des PFAS pourrait être restreinte, les évaluations des dangers et les mesures générales de gestion des risques pour surveiller et réduire les émissions dans l’environnement. Par ailleurs, le SEAC a entamé des discussions sur l’électronique et les semi-conducteurs.
https://echa.europa.eu/-/highlights-from-september-2025-rac-and-seac-meetings
L’Ineris publie un état des lieux sur les usages des PFAS et alternatives documentées, INERIS
Ce rapport dresse un panorama détaillé des usages des PFAS et de leurs alternatives, couvrant de nombreux secteurs et applications. Il peut servir d’outil de référence pour accompagner leur substitution progressive en France et en Europe
La restriction européenne des PFAS dans les mousses anti-incendie est adoptée, INERIS
Le 2 octobre 2025, la Commission européenne a adopté une restriction sur les substances per- et polyfluoroalkylées (PFAS) dans les mousses anti-incendie
Mapping of PFAS uses evaluated in the SEAC draft opinion, ECHA
L'ECHA prévoit de lancer la consultation sur le projet d'avis de son comité d'analyse socio-économique (SEAC) concernant la proposition de restriction des PFAS peu après son accord prévu en mars 2026. La consultation comprendra des questions générales sur tous les différents aspects couverts dans le projet d'avis du SEAC, ainsi que des questions détaillées sur chacune des évaluations sectorielles spécifiques réalisées par le comité. Afin d'aider les parties prenantes à identifier l'évaluation sectorielle à laquelle leur utilisation est soumise, l'ECHA publie cette première cartographie des utilisations des secteurs évalués dans le projet d'avis du SEAC. Une mise à jour de cette cartographie sera publiée après la réunion plénière du SEAC en décembre 2025, lorsque les évaluations sectorielles restantes auront été provisoirement conclues
https://echa.europa.eu/documents/10162/111425157/draft_use_mapping_pfas_en.pdf
Outil d’aide à l’identification des PFAS, INERIS
pfasID est un nouvel outil web dont le but est de faciliter l’identification des PFAS parmi les produits chimiques des chaînes d’approvisionnement. Cette identification s’appuie sur les bases de données de l’OCDE et de l’USEPA et sur des définitions de nomenclature chimique. Pour chaque produit saisi, pfasID fournit différents niveaux d’identification : « Pass » si la substance ne figure pas dans les bases de données et ne contient pas d'alerte structurelle ; « Fail » si la substance est répertoriée dans une des bases ; « Warning » si la structure de la substance indique un statut PFAS potentiel sur la base des définitions de l'ECHA, de l'OCDE, de l'Ontochem et/ou de l'EPA. Cet outil représente le premier volet du projet de PFACTS, visant à créer un centre d'échange de données, d'outils et de connaissances communautaires afin : De simplifier l'identification des produits chimiques et des matériaux PFAS ; D’accélérer la découverte d'alternatives plus sûres aux PFAS à l'aide de l'IA générative ; De recommander des méthodes pour éliminer les PFAS des applications industrielles jusqu'à la mise en place de substituts
Replay - Conférence Perturbateurs endocriniens, mythes et réalités / Afis Science - Association française pour l’information scientifique,
Conférence animée par Luc Multigner, Directeur de recherche émérite à l’Institut National de la Santé de de la Recherche Médicale (Inserm), spécialisé dans l’étude des conséquences sanitaires entrainés par les contaminants chimiques de l’environnement
https://www.afis.org/Video-Conference-Perturbateurs-endocriniens-mythes-et-realites
What you need to know about the updated PFAS restriction dossier, KEMI - Agence suédoise des produits chimiques
This summary sets out the main points of the Background Document for the proposed universal PFAS restriction under the REACH Regulation. The Background Document describes the environmental and human health risks associated with the use of PFASs and assesses the appropriateness (proportionality) of different restriction options to address them
Perturbateurs endocriniens : le Médipôle Hôpital Mutualiste propose une plateforme ludique et accessible à tous pour sensibiliser le grand public et les professionnels, 2025/11/14
Le Médipôle Hôpital Mutualiste, soutenu par l’ARS Auvergne-Rhône-Alpes, lance une plateforme de jeux en ligne pour sensibiliser le grand public aux perturbateurs endocriniens. Ludique et accessible, elle explique ce qu’ils sont, comment ils se cachent dans notre quotidien et propose des conseils pratiques pour réduire son exposition
Stratégie régionale sur les perturbateurs endocriniens en Auvergne-Rhône-Alpes, 2025/11/04
Découvrez la stratégie régionale sur les perturbateurs endocriniens en Auvergne-Rhône-Alpes, portée par l'ARS et ses partenaires. Axée sur la sensibilisation et la facilitation du passage à l’action, elle s’adresse de nombreux acteurs : établissements de santé, collectivités, acteurs de la petite enfance, PMI... A travers ces professionnels relais, elle s’adresse aux parents
Assessment of bisphenol-related knowledge and awareness among healthcare professionals: a cross-sectional analysis from Turkiye,
Aslan, E. and Kaplan, B., Frontiers in Public Health, Sep 12 2025, Vol. 13.
https://doi.org/10.3389/fpubh.2025.1627745
A comprehensive review of emerging environmental contaminants of global concern,
Boahen, E., Owusu, L. and Adjei-Anim, S. O., Discover Environment, Sep 16 2025, Vol. 3, no. 1.
https://doi.org/10.1007/s44274-025-00259-x
The impact of chemical pollution and warming on male fertility: a narrative review by the Special Interest Group "Environment and Fertility" of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR),
Defeudis, G., De Angelis, C., Mazzilli, R., Barbagallo, F., Leanza, C., Sabovic, I., Condorelli, R. A., Rago, R., Gianfrilli, D., Pivonello, R., Di Nisio, A., Anserini, P., Foresta, C. and Italian Soc Fertility Sterility Reprod Med, S. M., Journal of Assisted Reproduction and Genetics, 2025.
https://doi.org/10.1007/s10815-025-03678-0
Membrane technologies for endocrine-disrupting chemical removal: A state-of-the-art review on materials, mechanistic insights, and future directions,
Lgaz, H., Zouhair, F. Z., Benkhaya, S., Lee, H. S. and Messali, M., Separation and Purification Technology, Feb 7 2026, Vol. 380.
https://doi.org/10.1016/j.seppur.2025.135218
Perturbateurs endocriniens et perception des risques avant, pendant et après la grossesse : une revue systématique de la littérature,
Musso, A., Chevalier, N., Bailly, L. and Pradier, C., Gynécologie Obstétrique Fertilité & Sénologie, 2025/11/01/ 2025, Vol. 53, no. 11, p. 622-623.
https://doi.org/10.1016/j.gofs.2025.09.041
Taxation de l’hexane : comprendre la controverse avec Guillaume Coudray,
O'gomes, I. D., Sciences et Avenir, 2025/11/10/T09:47:31.000Z 2025. https://www.sciencesetavenir.fr/nutrition/hexane-un-solvant-sur-la-sellette-le-decryptage-de-guillaume-coudray-apres-le-vote-des-deputes_189243
Le plus grand groupe chimique mondial abandonnera définitivement les PFAS, ces produits chimiques appelés « polluants éternels » d’ici 2028
Res (2025). Réseau Environnement Santé. https://www.reseau-environnement-sante.fr/le-plus-grand-groupe-chimique-mondial-abandonnera-definitivement-les-pfas-ces-produits-chimiques-appeles-polluants-eternels-dici-2028/
Pesticides, an urgent challenge to global environmental health and planetary boundaries,
Vandenberg, L. N., Pierce, E. J. and Arsenault, R. M., Frontiers in Toxicology, Oct 3 2025, Vol. 7.
https://doi.org/10.3389/ftox.2025.1656297
Environmental Chemicals and Female Reproductive Health: Unraveling Mechanisms and Societal Impacts - A Narrative Review,
Xie, Y. D., Peng, R. T. and Xiao, L., Clinical and Experimental Obstetrics & Gynecology, Jul 31 2025, Vol. 52, no. 8.
https://doi.org/10.31083/ceog39882
Toxicité sur les animaux
Perinatal exposure to BPA leads to pronounced prostatic morphophysiological disorders in a rodent model of induced hyperplasia,
Bicalho-Silva, S., Grigio, V., Ruiz, T. F. R., Calmon, M. D., Rahal, P., Taboga, S. R., Dos Santos, F. C. A. and Vilamaior, P. S. L., Molecular and Cellular Endocrinology, Dec 1 2025, Vol. 610.
https://doi.org/10.1016/j.mce.2025.112664
Endocrine effects of Imazalil on aromatase expression, vitellogenesis and ovarian histology using cyp19a1a-eGFP-casper transgenic zebrafish,
De Oliveira, J., Ly, T. K., Chadili, E., Thermes, V., Mergot, A., Piccini, B., Palluel, O., Budzinski, H., Le Menach, K., Pardon, P., Beaudouin, R., Cousin, X., Brion, F. and Hinfray, N., Aquatic Toxicology, Dec 2025, Vol. 289.
https://doi.org/10.1016/j.aquatox.2025.107580
Influence of perinatal exposure to an endocrine disruptor mixture on the renal microenvironment of aged male rat offspring: histopathological aspects,
Dolfini, P. M., Hinokuma, K. D., Nai, G. A., Castilho, A. C. D. and Mendes, L. D., Journal of Developmental Origins of Health and Disease, Sep 1 2025, Vol. 16.
https://doi.org/10.1017/s2040174425100172
Androgen receptor antagonist flutamide modulates estrogen receptor alpha expression in distinct regions of the hypospadiac rat penis,
Elmelund, E., Draskau, M. K., Berg, M., Strand, I. W., Black, J. R., Axelstad, M., Pask, A. J. and Svingen, T., Frontiers in Endocrinology, Sep 12 2025, Vol. 16.
https://doi.org/10.3389/fendo.2025.1654965
Perinatal neurodevelopmental effects of endocrine disruptors: Insights from metabolome mapping in the rat hippocampus,
Evangelista, S., Lichtensteiger, W., Schlumpf, M., Rancan, L., Paredes, S. D., Linillos-Pradillo, B., Lamoree, M. H. and Leonards, P. E. G., Toxicology, Dec 2025, Vol. 518.
https://doi.org/10.1016/j.tox.2025.154281
Benzophenone-3 (BP3), bisphenol A (BPA), and their combination impair ovarian response to gonadotropin stimulation in a multi-exposure multiparity model,
Galliani, V., Fessia, J., Santamaria, C. G., Abud, J. E. and Rodriguez, H. A., Environmental Toxicology and Pharmacology, Oct 2025, Vol. 119.
https://doi.org/10.1016/j.etap.2025.104821
Concentration-Related Ultrastructural Alterations in Mouse Oocytes Following In Vitro Lindane Exposure,
Gatti, M., Belli, M., De Rubeis, M., Nottola, S. A., Macchiarelli, G., Tatone, C., Di Emidio, G. and Palmerini, M. G., Applied Sciences-Basel, Jul 26 2025, Vol. 15, no. 15.
https://doi.org/10.3390/app15158320
Exposure to Kalach, a Glyphosate-Based Herbicide, During Pregnancy and Lactation Induces Hypothyroidism and Bone Disorders in Rat Offspring,
Hamdaoui, L., El Feki, H., Ben Amor, M., Oudadesse, H., Atwan, M., Alshammari, A. M., Brahmi, F., Ben-Nasr, H., Badraoui, R. and Rebai, T., Toxics, Sep 4 2025, Vol. 13, no. 9.
https://doi.org/10.3390/toxics13090752
Pesticide-induced epigenetic suppression of WNT signaling and NF-κB-driven inflammation impairs ovarian function in rats,
Jan, J., Sheikh, W. M., Gul, S., Mohidin, R., Bhat, O. M., Lone, M. N., Shah, S. A., Dar, A. H., Zargar, M. A., Bashir, S. M. and Wani, N. A., Food and Chemical Toxicology, Nov 2025, Vol. 205.
https://doi.org/10.1016/j.fct.2025.115706
The effects of bisphenol compounds on endocrine disruption and reproductive function from epidemiological analysis to animal exposure: A mixture analysis,
Jiang, P. Y., Wang, W. W., Li, J. D., Li, Y. T., Ji, X. T. and Yue, H. F., Journal of Environmental Sciences, Feb 2026, Vol. 160, p. 537-547.
https://doi.org/10.1016/j.jes.2025.04.042
Integrated transcriptome analysis of rats exposed to bisphenol mixtures from the fetal to developmental stage,
Jung, S., Quah, Y., Ham, O., Kim, S., Jeong, J. S., Kim, W., Lee, S. J. and Yu, W. J., Toxicology Research, Aug 2025, Vol. 14, no. 4.
https://doi.org/10.1093/toxres/tfaf120
Effects of TBBPA Exposure on Neurodevelopment and Behavior in Mice,
Kim, Y., Hwang, I., Kim, S. and Jeung, E. B., International Journal of Molecular Sciences, Jul 28 2025, Vol. 26, no. 15.
https://doi.org/10.3390/ijms26157289
Implications of a combined perinatal exposure to BPA and BP-3 for offspring folliculogenesis and ovarian function in mice,
Krieger, E., Fischer, F., Howanski, J., Wagner, M., Romanelli, F., Fink, B., Bauer, M., Schumacher, A., Kretschmer, T. and Zenclussen, A. C., Ecotoxicology and Environmental Safety, Sep 1 2025, Vol. 302.
https://doi.org/10.1016/j.ecoenv.2025.118750
Imidacloprid actions in the mouse mammary gland structure and epithelial mammary cells. Role of GPER and nAChR,
Leguizamón, M. A., Buján, S., Sánchez, Y., Pontillo, C., Chiappini, F., Español, A., Randi, A. and Miret, N., Environmental Research, Nov 15 2025, Vol. 285.
https://doi.org/10.1016/j.envres.2025.122620
The Physiopathological Link Between Bisphenol A Exposure and Molar Incisor Hypomineralization Occurrence: A Systematic Review,
Mathonat, E., Canceill, T., Marty, M., Prosper, A., Vinel, A. and Noirrit-Esclassan, E., Dentistry Journal, Jul 22 2025, Vol. 13, no. 8.
https://doi.org/10.3390/dj13080332
Transcriptomic Changes Across the HPG Axis Following Prenatal Exposure to the EDC Mixture NeuroMix,
Milewski, T. M., Streifer, M., Thompson, L. M., Sheinhaus, D., Hynes, A. and Gore, A. C., Endocrinology, Oct 2025, Vol. 166, no. 10.
https://doi.org/10.1210/endocr/bqaf135
Maternal exposure to tributyltin alters female reproductive system development,
Miranda, R. A., Da Silva, B. S., Bertasso, I. M., De Souza, L. L., Maas, E., Graceli, J. B., Miranda-Alves, L., De Moura, E. G. and Lisboa, P. C., Journal of Endocrinology, Aug 1 2025, Vol. 266, no. 2.
https://doi.org/10.1530/joe-24-0357
Elucidating the impact of persistent organic pollutants on male reproductive health and testicular structure,
Ray, S. S., Gupta, P., Mahapatra, A., Suman, A. and Singh, R. K., Toxicology Letters, Aug 2025, Vol. 411, p. 37-49.
https://doi.org/10.1016/j.toxlet.2025.07.002
Reproductive Effects of Endocrine Disruptors in Domestic Ruminants: Integrating In Vitro and In Vivo Evidence,
Sapanidou, V. G., Lavrentiadou, S. N. and Tsantarliotou, M. P., Animals, Sep 16 2025, Vol. 15, no. 18.
https://doi.org/10.3390/ani15182712
Maternal Phthalate Exposure Alters Prostate Proteome in Rat Offspring: Linking Omics Insights to Prostate Cancer Risk in Humans,
Souza, P. V., Aquino, A. M., Alonso-Costa, L. G., De Oliveira, M. a. F., Rocha, V. A., Fioretto, M. N., Moreira, M. F., Pinha, V. C., Caxali, G. H., Justulin, L. A., Flaws, J. A. and Scarano, W. R., Archives of Medical Research, Feb 2026, Vol. 57, no. 2.
https://doi.org/10.1016/j.arcmed.2025.103297
The effect of maternal sodium ρ-perfluorous nonenoxybenzene sulfonate exposure on the gut microbiota in dams and offspring,
Wang, C. Y., Ping, F. F., Tong, Q., Li, Y. Y. and Jin, Y. X., Scientific Reports, Aug 25 2025, Vol. 15, no. 1.
https://doi.org/10.1038/s41598-025-15021-9
Per- and polyfluoroalkyl substances in dog blood serum levels and semen quality,
Weiss, J., Engelhardt, J., Holst, B. S., Al-Sarraj, R. and Hallberg, I., Frontiers in Endocrinology, Oct 1 2025, Vol. 16.
https://doi.org/10.3389/fendo.2025.1643703
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Écrit par NathalieAdmin